침습성 결직장 암종에서 PCNA 및 nm23 발현의 임상적 의의
Clinical Significance of PCNA and nm23 Expression in Invasive Colorectal Carcinoma
강구, 박철재,
소속 상세정보
강구 ( Kang Gu )
강원대학교 의과대학 병리학교실
박철재 ( Park Chul-Jae )
한림대학교 의과대학 외과학교실
KMID : 0356720010170010047
Abstract
Purpose: It is known that PCNA (proliferating cell nuclear antigen) is associated with cell proliferating activity and nm23 with so called ’anti-metastatic’ activity. We tried to elucidate the relationships of PCNA labeling index and nm23
expression in carcinoma cells with survival rates of patients with invasive colorectal carcinoma.
Methods: Immunohistochemical study was performed using monoclonal antibodies for PCNA and nm23 gene products on 45 cases of paraffin-embedded tissue made of invasive colorectal cancer.
Results: Five-year survival rate was lower in the group with high PCNA labeling index than that with low one, but PCNA labeling index was not associated with the tumor stages. Expression of nm23 was not associated with survival rate, tumor stage, site, and PCNA labeling index.
Conclusion: Although PCNA labeling index was not associated with tumor stages, this study suggests that PCNA labeling index will be a good prognostic factors in invasive colorectal carcinoma.
키워드
결직장암
PCNA;nm23;Colorectal carcinoma
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