Helicobacter pylori 와 대장의 신생물과의 연관성
Association between Helicobacter pylori and Colorectal Neoplasm
안중욱, 류재현, 김광호, 박응범,
소속 상세정보
안중욱 ( Ahn Joong-Wook )
이화여자대학교 의과대학 일반외과학교실
류재현 ( Ryu Jae-Hyun )
이화여자대학교 의과대학 일반외과학교실
김광호 ( Kim Kwang-Ho )
이화여자대학교 의과대학 일반외과학교실
박응범 ( Park Eung-Bum )
이화여자대학교 의과대학 일반외과학교실
KMID : 0356720010170030125
Abstract
Purpose: Helicobacter pylori infection has been reported as a major factor of chronic gastritis, peptic ulcer, gastric lymphoma, and stomach cancer. In some uncontrolled studies, a high seroprevalence of H. pylori infection unexpectedly has been found in patients with colorectal cancer. The purpose of this study was to investigate the prevalence of H. pylori infection in patients with colorectal neoplasm.
Methods: 93 colonic tissue samples were collected during the colonoscopic biopsy. The specimens included polyp, cancer, and normal colonic mucosa. The CLO testTM kit (Delta West Ltd., Bentley, Western Australia) was used for detection of H. pylori. The SAS program (USA) was used for the Fisher’s exact test.
Results: H. pylori infection was detected 11 (11.8%) of total 93 specimens, 7 (25.7%) of 27 in cancers and 3 (6.9%) of 43 in polyps. Significantly higher H. pylori infection was detected in the colorectal cancers than non-cancer lesions (p=0.012) and polyps (p=0.038).
Conclusion: These results suggest a statistically significant association between H. pylori and colorectal neoplasm. The mechanism underlying this association needs to be investigated.
키워드
Helicobacter pylori 대장 신생물
Helicobacter pylori Colorectal neoplasia;CLO test
원문 및 링크아웃 정보
등재저널 정보