Paraquat에 의한 폐섬유증조직내의 Fibronectin의 면역조직학적 검색
Immunohistochemical Demonstration of Fibronectin in Paraquat-Induced Interstitial Fibrosis of Adult Human Lung
홍승표, 남성일, 권영철,
소속 상세정보
홍승표 ( )
계명대학교 의과대학 병리학교실
남성일 ( )
계명대학교 의과대학 병리학교실
권영철 ( )
계명대학교 의과대학 병리학교실
KMID : 0357919870210030138
Abstract
We studied the distribution of fibronectin in paraquat-induced adult fibrotic lung by
indirect immunofluorescence and indirect immunoperoxidase methods, using
affinity-purified antifibronectin IgG peroxidase conjugates and antifibronectin IgG FITC
conjugates.
In contrast to the relative paucity of staining in normal lung, there was a marked
increase in interstitial staining for fibronectin in this fibrotic lung. This marked
alterations in the apparent amounts and distribution of fibronectin in fibrotic human lung
suggest its involvement in the cellular events accompanying human lung fibrosis.
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