광견의 소뇌에서 발견한 Negri소체 -광학 및 전자현미경 소견-
Negri Bodies in Rabid Dog - Light and Electron Microscopic Findings -
소속 상세정보
박언섭/Eon Sub Park
박용욱/유재형/송계용/지제근/Young Uk Park/Jae Hyung Yoo/Kye Yong Song/Je G. Ghi
KMID : 0357919920260060615
Abstract
요약
저자들은 가상바이러스에 감염되었다고 의심되어 관찰하던 중 심한분비물과 공격적 발작을
취하다가 사망한 개의 뇌조직에서 전반적인 미만성 뇌염의 소견과 더불어 소뇌에서 Negri소체를
관찰하여 광견병으로 확인한 한 증례를 기술하였다. Negri소체는 소뇌의 Purkinje 세포에서만 관찰되었으며 둥근
호산성의 세포질내 봉입체로 관찰되었다. 소뇌의 전자현미경 검사결과 특징적 탄환 모양의 nucleocapsid 구조를
가지는 rabies virus를 확인할 수 있었으며 이는 가상바이러스에 감염된 개에서 드물게 기술되어 있어 간단한 문헌고찰을 하였다.
#초록#
Rabies is a fatal viral encephalitis to which all mammals, including man are
susceptible. This virus, the genus of Rhabdovirus, is usually present in the saliva of
infected animals and is transmitted by their bite. As a rule the virus enter the CNS by
ascending along peripheral nervous system and extremely variable in extent.
Negri bodies are appear in about 75% of cases. These bodies are eosinophilic, usually
rounded inclusions and is located in the cystoplasm of the neurons, most frequently in
the pyramidal neurons of the Hippocampus and the Purkinje cells of the cerebellum.
We have experienced a case of canine rabies that showed Negri bodies in the Purkinje
cells along with diffuse degenerative encephalitis and perivascular mononuclear cells
infiltration. The Negri bodies were best demonstrated by Negri body staining although
routine H-E staind was also useful. There inclusion bodies were located exclusively in
the cytoplasm, and were found occasionally. Electron microscopic findings of the Negri
bodies showed aggregates of bullet shaped nucleocapsids.
We report a Negri body found in the brain of rabid dog with the light and electron
microscopic findings. (Korean J Pathol 1992; 26: 615∼619)
키워드
Negri body; Rabies; Dog; Purkinje cell;
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