유방암종에서 E-Cadherin세포부착분자의 발현과 암종의 조직학적 분화도 및 호르몬 수용체와의 상관관계에 대한 연구
E-Cadherin Expression in Breast Carcinoma: Correlation with Tumor Grade and Hormone Receptor
대한병리학회지 1997년 31권 11호 p.1172 ~ 1179
박찬금, 강행자, 박찬필,
소속 상세정보
박찬금 ( )
한양대학교 의과대학 병리학교실
강행자 ( )
삼성제일병원 병리학교실
박찬필 ( )
삼성제일병원 병리학교실
KMID : 0357919970310111172
Abstract
E-cadherin (E-CD), a Ca2+ -dependent adhesion molecule, plays a major
role in the maintenance of intercellular junctions in normal epithelial cells in mosts
organs. Recently, a correlation has been observed between a loss of E-CD and increased
invasiveness of neoplastic cells. In this study, E-CD expression in the breast carcinoma
was investigated using monoclonal antibody, anti-E-CD by immunohistochemical method.
Expression of E-CD were evaluated in 57 breast carcinomas and correlated with their
tumor grade, lymph node involvement, and hormonal receptor status. Histological types
included in this study were 54 invasive ductal carcinomas (IDCs) of otherwise not
specified and 3 invasive lobular carcinomas. Cases of histologic grade Ⅰ IDC were 6,
grade Ⅱ 30, and grade Ⅲ 18. Of 54 IDCs 39 (72.2%) showed moderate to strong linear
staining at the cell borders regardless of their histologic grade, status of lymph node
metastasis, and status of hormone receptor. Staining intensity of E-CD was reduced in
54 cases(83%) of IDC when compared with that of normal or benign breast lesions
(P<0.01). All .seven cases of intraductal carcinoma, which .were included in 54 IDCs
showed one or two grade reduced expression of E-CD than that of infiltrative lesions.
Three invasive lobular carcinomas showed strong (1 case), moderate (1 case), and
negative reactivity (1 case). The data indicated that loss of E-CD expression is a c겨
cial event in the development of breast carcinoma.
키워드
E-Cadherin; Breast carcinoma; Tumor grade; Hormone receptor;
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