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Àç¹ß ¹× ¾Ç¼º ÀüȯÀ» º¸ÀÎ ¼ö¸·Á¾ -MIB1, p53°ú progesterone receptorÀÇ Ç¥Çö- Meningioma with Multiple Recurrences and Malignant Transformation -Differences in expression of MIB1, p53 and progesterone receptor-

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Abstract

¼ö¸·Á¾Àº µÎ°³³»¿¡¼­ ÈçÈ÷ »ý±â´Â Á¾¾çÀÌ¸ç ´ëºÎºÐÀÇ °æ¿ì ¾ç¼ºÀÌ´Ù. ±×·¯³ª ¼ö¼ú ÈÄ 10
³â µ¿¾È¿¡ 13¡­25%°¡ Àç¹ßÇϸç, Á¶Á÷ÇÐÀûÀÎ ¼Ò°ß¸¸À¸·Î´Â ¿¹Èĸ¦ ¾Ë±â°¡ ¾î·Æ´Ù. µû¶ó¼­ ÃÖ
±Ù¿¡´Â Á»´õ °´°üÀûÀ¸·Î ¿¹Èĸ¦ ¾Ë¾Æ³»±â À§·¡ ¼¼Æ÷ÀÇ Áõ½ÄÇ¥Áö³ª p53 °°Àº Á¾¾ç¾ïÁ¦ÀÎÀÚ,
¼ºÈ£¸£¸ó¼ö¿ëü µîÀÇ Ç¥ÇöÀ» Á¶Á÷°Ëü¿¡¼­ °Ë»çÇÏ°í ÀÖ´Ù. ÀúÀÚµéÀº 14³â¿¡ °ÉÃÄ ¼¼Â÷·Ê³ª
Àç¹ßÇÏ´Â °úÁ¤¿¡¼­ ¸¶Áö¸·¿¡´Â ¾Ç¼ºÀüȯ±îÁö ÀÏÀ¸Å² µå¹°°Ô º¸´Â ¼ö¸·Á¾ 1¿¹¸¦ °æÇèÇÏ°í,
°°Àº ȯÀÚÀÇ ´Ù¸¥ ½Ã±â¿¡ »ý±ä 4°¡Áö Á¾¾ç¿¡ MIB1, p53 ¹× ÇÁ·Î°è½ºÅ×·Ð ¼ö¿ëü(PgR)¿¡ ´ë
ÇÑ ¸é¿ªÈ­Çп°»öÀ» ½ÃÇàÇÏ¿© ±× Ç¥ÇöÀÌ ¾î¶»°Ô ´Þ¶óÁ³´ÂÁö¸¦ ¾Ë¾Æº¸¾Ò´Ù.
#ÃÊ·Ï#
We describe herein a case of meningioma showing three recurrences and in the end
malignant transformation. To compare the differences of MIB1, p53 and progesterone
receptor expressions in benign, recurrent and malignant meningiomas of the same
patient, we performed immunohistochemical stainings for those markers. MIB1 and p53
reactivities were increased in proportion to histologic aggressiveness. By contrast, the
progesterone receptor expression was noted in benign meningioma but not in malignant
meningioma.

Å°¿öµå

Meningioma; Malignant transformation; MIB1; p53; Progesterone receptor;

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