한국인전립선선암종의병리학적분석: 83예의지도화분석
Pathologic Features of Korean Prostate Adenocarcinoma : Mapping Analysis of 83 Cases
이유정, 박원서, 홍은경, 김동일, 이건국, 이희은, 원재경, 이강현,
소속 상세정보
이유정 ( Lee You-Jeong )
서울대학교병원 병리학교실
박원서 ( Park Weon-Seo )
국립암센터 병리과
홍은경 ( Hong Eun-Kyung )
국립암센터 병리과
김동일 ( Kim Dong-Il )
서울대학교병원 병리학교실
이건국 ( Lee Geon-Kook )
국립암센터 병리과
이희은 ( Lee Hee-Eun )
서울대학교병원 병리학교실
원재경 ( Won Jae-Kyung )
서울대학교병원 병리학교실
이강현 ( Lee Kang-Hyun )
국립암센터 특수암센터
KMID : 0357920060400030204
Abstract
Background: Prostatic adenocarcinoma makes up about 2% of the total cancer incidence and cancer death in Korean men, but the incidence of this malady is continuously increasing. So far, there have been only a few studies describing the pathologic characteristics of the prostatic adenocarcinoma in Korean patients. In this study, we analyzed 83 radical prostatectomy specimens by using mapping analysis to discover the clinico pathologic characteristics of Korean prostatic adenocarcinoma.
Methods: The resected prostates were serially sectioned and embedded for histologic mapping. The clinico pathologic findings, including the Gleason score, tumor size, prostate intraepithelial neoplasia (PIN) and tumor invasion to the surrounding tissues, were examined.
Results: The mean values were as follows: age, 64.1±6.6 years; serum prostate specific antigen (sPSA), 16.6±16.2 ng/mL; tumor volume, 22.3±22.4% tumor size, 2.2±1.2 cm; and Gleason score, 6.9±0.9. The rate of high grade PIN was 79.7%. The Gleason score, tumor extent and T stage were statistically correlated (p<0.05).
Conclusions: Some prognostic factors such as sPSA and the Gleason scores showed significantly lower levels compared with those of the previous studies on Korean prostate adenocarcinoma (16-36 ng/mL vs 16.6 ng/mL and 7.3-7.7 vs 6.9, respectively). Although these values are still higher than those of the western studies, this study implies that the early detection of pro- state adenocarcinoma is increasing in Korea.
키워드
Prostate;Adenocarcinoma;Prostate specific antigen;Koreans
원문 및 링크아웃 정보
등재저널 정보