대장암종에서 HSP 70의 예후 인자로서의 의의
Prognostic Value of HSP 70 in Colorectal Cancer
윤상호, 차성재, 박성일, 이태진, 임현묵, 박성준, 김형중,
소속 상세정보
윤상호 ( Youn Sang-Ho )
중앙대학교 의과대학 외과학교실
차성재 ( Cha Sung-Jae )
중앙대학교 의과대학 외과학교실
박성일 ( Park Sung-Il )
중앙대학교 의과대학 외과학교실
이태진 ( Lee Tae-Jin )
중앙대학교 의과대학 병리학교실
임현묵 ( Lim Hyun-Muk )
중앙대학교 의과대학 외과학교실
박성준 ( Park Sung-Jun )
중앙대학교 의과대학 외과학교실
김형중 ( Kim Hyung-Jung )
중앙대학교 의과대학 병리학교실
KMID : 0371320010600050531
Abstract
Purpose: To evaluate the relationships between the expression of HSP 70 and prognostic factors, including T-stage, lymph node metastasis, distant metastasis, stage, differentiation and survival rate in colorectal cancer.
Methods: We studied 62 patients with colorectal cancer in order to evaluate the relationships between the expression of HSP 70 and multiple prognostic factors, including T-stage, lymph node metastasis, distant metastasis, stage and
differentiation.
Results: There was no statistically significant correlation among HSP 70, T-stage, lymph node metastasis, distant metastasis, stage and differentiation. However, in our study, the expression of HSP 70 was slightly elevated in case with no lymph node metastasis, a lower stage and well differentiated colorectal cancer. In regards to survival, the overall survival rate was lower in the group with positive HSP 70 vice the negative group, and this was statistically significant.
Conclusion: HSP 70 expression and the prognostic factors of colorectal cancer appear not to be correlated to each other, although HSP 70 may play a certain role in colorectal cancer. Further studies are required for determining the prognostic factors in colorectal cancer.
키워드
HSP 70;대장암종
Heat shock protein (HSP) 70;Colorectal cancer
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