35세 이하 젊은 연령에 발생한 유방암의 임상적 특징과 예후
Clinical Characteristics and Prognosis of Young Age (35 year old or younger) onset Breast Cancer
민연기, 김종한, 조성진, 김남렬, 구범환, 황정웅, 배정원,
소속 상세정보
민연기 ( Min Youn-Ki )
고려대학교 의과대학 외과학교실
김종한 ( Kim Jong-Han )
고려대학교 의과대학 외과학교실
조성진 ( Cho Seong-Jin )
고려대학교 의과대학 병리학교실
김남렬 ( Kim Nam-Ryeol )
고려대학교 의과대학 외과학교실
구범환 ( Koo Bum-Hwan )
고려대학교 의과대학 외과학교실
황정웅 ( Whang Jeong-Woong )
고려대학교 의과대학 외과학교실
배정원 ( Bae Jung-Won )
고려대학교 의과대학 외과학교실
KMID : 0371320010600060612
Abstract
Purpose
The question of whether ’young age onset’ is a single prognostic factor for breast cancer has been controversial. The incidence of breast cancer according to age differs by region and races. The purpose of this study was to determine the
incidence
of
breast cancer in women 35 year old or younger and elucidate its clinical characteristics, prognosis, and differences from older age onset breast cancer.
Methods
A retrospective study of 545 consecutive breast cancer patients who had been treated at our hospital from 1990 to 1999, was conducted. We investigated the ratio of 35 year old or younger breast cancer patients, age of menarche, TNM stage,
histologic
grades, hormone receptor status, survival rates. This was then compared with the counter age (＞35) group’s data. The significances of the differences were evaluated by variable type using the Student’s t-test or chi-square test. Analysis was
performed
using SPSS software.
Results
The younger age group patients numbered 62 (11.3%) among the total group, and showed earlier menarche, worse histologic differentiation, and lower mammographic detection rate than the counter group (P＜0.05). There were no differences in TNM
stage
distribution or hormone receptor expression status according to age group (P＞0.05). The young age group’s 5 year overall and disease free survival rates were 83±5% and 58±8% respectively and both were lower than the counter group’s 89±2% and
74±3%
(P＜0.05), respectively additionally, the age adjusted overall and disease free survival rates were worse than the counter age group’s.
Conclusion
The younger age group showed worse survival rates, poorer prognostic factors and a higher late of early relapse rate than the older age group. Therefore, we may consider ’young age onset’ to be a poor prognostic factor in breast cancer.
키워드
유방암; 젊은 연령; 예후; 생존율; Breast cancer; Young age; Prognosis; Survival rate;
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