유방의 양성 및 악성 유두상 종양에서 Cyclin D1, MIB-1 단백 발현의 의의
Significance on the Expression of Cyclin, MIB-1 in Benign and Malignant Papillary Lesion of the Breast
안우석, 김태현, 이진용,
소속 상세정보
안우석 ( Ahn Woo-Seok )
인제대학교 의과대학 부산백병원 외과학교실
김태현 ( Kim Tae-Hyeon )
인제대학교 의과대학 부산백병원 외과학교실
이진용 ( Lee Jin-Yong )
인제대학교 의과대학 부산백병원 외과학교실
KMID : 0371320010610010013
Abstract
Purpose
It is difficult at times to differentiate between a papillary carcinoma and benign papilloma of the breast, and papillomas can undergo malignant transformation. The authors investigated the expression of cyclin D1 and MIB-1 to assess the
diagnostic
value of these markers in distinguishing papillary carcinomas from papillomas of the breast, and in determining the clinical relevance of these markers as prognostic predictors.
Methods
The medical records of 38 patients treated for benign and malignant papillary lesions of the breast at Inje University Pusan Paik Hospital between January 1992 and December 1997 were reviewed. Immunohistochemical stains for cyclin D1 and MIB-1
were
performed in 30 cases of papilloma and eight cases of papillary carcinoma of the breast. The authors performed a statistical analysis of the relationship between cyclin D1 and MIB-1 with respect to the size of tumors, pathologic lymph nodes, and
postsurgical residual lesions, and the recurrence and survival rates.
Results
Breast cancer or ADH was associated with six cases (15.79%) of papillary lesions of the breast. The incidence of postsurgical residual lesions and their recurrence were 2.63% and 2.63% in all the patients with papillary lesions of the breast. The
labeling index of cyclin D1 was significantly higher in the eight papillary carcinomas (36.7±27.0) than in the 30 papillomas (3.5±4.2) (P=0.001). There was a statistically significant difference betweenn the MIB-1 labeling index of the eight
papillary
carcinomas (4.9±5.9) and that of the 30 papillomas (0.4±1.4) (P=0.0225). The cyclin D1 and MIB-1 expressions of the single intraductalpapillomas and multiple papillomas were not different. In addition, there was no statistically significant
difference
of cyclin D1 and MIB-1 in the eight papillary carcinomas with respect to the associated pathologies, size, positive lymph nodes, recurrence or survival.
Conclusion
These results suggest that cyclin D1 and MIB-1 might be useful markers for distinguishing papillary carcinomas from papillomas of the breast.
키워드
유두종; 악성 유두상 종양; Cyclin D1; MIB-1; Papilloma; Papillary carcinoma; Cyclin D1; MIB-1;
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