유방의 파제트씨 병의 임상적 고찰
Paget’s Disease of the Breast
김현태, 이진용,
소속 상세정보
김현태 ( Kim Hyun-Tae )
인제대학교 의과대학 부산백병원 외과학교실
이진용 ( Lee Jin-Yong )
인제대학교 의과대학 부산백병원 외과학교실
KMID : 0371320010610010040
Abstract
Purpose
Paget’s disease of the breast (PDB) occurs in approximately 1∼3% of all primary breast carcinomas. This study aimed to determine the optimal surgical treatments for PDB in this study.
Methods
The medical records of 16 patients with PDB who had been treated between January 1986 and December 1998 were clinically reviewed retrospectively.
Results
13 patients had nipple changes consistent with clinical Paget’ disease (CPD) including 8 who had an associated breast mass, and 5 who had no associated mass. Of the 13 patients with CPD, 12 were treated with a modified radical mastectomy while 1
was
treated with a radical mastectomy. Breast cancer (BC) was found in all of 13 patients (100%) with CPD. The BC was centrally located in 46% of patients including 38% in CPD associa
ted with the mass and 60% in CPD not associated with the mass. Out of 8 CPD patients associated with the mass, 7 (88%) had invasive cancer, 1 (12%) had a ductal carcinoma in situ (DCIS), and 2 (25%) had pathologic axillary nodes (PAN). The 5 year
survival rate was 87.5%. Of the 5 CPD patients not associated with the mass, 4 (80%) had an invasive cancer, 1 (20%) had a DCIS and none had PAN. Their 5 year survival rate is 100%.
Conclusion
All the patients with CPD had an associated BC. BC is more frequently centrally located in the CPD not associated with the mass (60%) than those associated with the mass (38%). Contrarily, the BC in CPD that was not associated with the mass was
located
more peripherally (40%). Therefore, the treatment of patients with CPD must be individualized in order to avoid under or overtreatment.
키워드
파제트씨 병; 내재 유방암; 액와임파선; Paget’s disease; Breast cancer; Axillary lymph node;
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