유방암 환자의 흉벽 및 피부재발에 대한 광역동치료의 경험
Experience of Photodynamic Therapy for Palliation of the Chest Wall and Skin Recurrence in a Patient with Breast Cancer
윤호성, 고창대, 강희준, 안세현,
소속 상세정보
윤호성 ( Yoon Ho-Sung )
울산대학교 의과대학 외과학교실
고창대 ( Ko Chang-Dae )
울산대학교 의과대학 외과학교실
강희준 ( Kang Hee-Joon )
울산대학교 의과대학 외과학교실
안세현 ( Ahn Sei-Hyun )
울산대학교 의과대학 외과학교실
KMID : 0371320020620010082
Abstract
In patient treated by mastectomy for breast cancer, chest wall and skin recurrences are frequently encountered. Chest wall recurrence results in profound physical and psychological morbidity, and often heralds the appearance of other, more life
threatening metastasis. Traditionally the two most common treatments have been site-specific radiation and resection. Photodynamic therapy (PDT) provided an alternative treatment modality using a photosensitizer and laser light to induce
selective
tumor
necrosis. The patient was 64-years old female, had undergone breast conserving surgery for cancer of the right breast. Chest wall and skin metastasis recurred at 40 months after the adjuvant treatment of chemotherapy. The lesions were progressed
despite
2nd, 3rd chemotherapy and hyperth ermal therapy. The light was administered through a diode laser turned to 630 ㎚ wave length (150 J/㎠ in light dosage, 200 ㎽/㎠ in intensity), 72 h after photosensitizing agent injection. There was clinical
evidence
of partial response, defined as granulation tissue with re-epitheliaization from the periphery of normal epithelium. PDT has demonstrated good results in other solid tumors at some hospitals, however there has been no application for breast
cancer
in
Korea previously. Our experience suggests that PDT is non-invasive procedure that is highly tolerable, particularly when compared with other modalities, and an effective treatment method for chest wall or skin recurrence that shows no response to
other
treatments.
키워드
유방암; 광역동치료; 흉벽재발; Breast cancer; Photodynamic therapy; Chest wall recurrence;
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