개의 동종 부분 간이식 후 허혈-재관류 손상에 대한 가돌리늄 클로라이드의 효과
Ischemia-reperfusion Injury after Canine Liver Allo-transplantation The Effect of Gadolinium Chloride
정구용, 성순희, 정규영, 오수연, 김유선, 조백환, 최금자, 최용만,
소속 상세정보
정구용 ( Chung Ku-Yong )
이화여자대학교 의과대학 외과학교실
성순희 ( Sung Sun-Hee )
이화여자대학교 의과대학 병리학교실
정규영 ( Jung Gyu-Young )
이화여자대학교 의과대학 외과학교실
오수연 ( Oh Soo-Youn )
이화여자대학교 의과대학 외과학교실
김유선 ( Kim Yu-Seun )
연세대학교 의과대학 외과학교실
조백환 ( Cho Baik-Hwan )
전북대학교 의과대학 외과학교실
최금자 ( Choi Kum-Ja )
이화여자대학교 의과대학 외과학교실
최용만 ( Choi Yong-Man )
이화여자대학교 의과대학 외과학교실
KMID : 0371320020630050360
Abstract
Purpose: The effective suppression of Kupffer cell function is believed to contribute to the prevention of preservation/ reperfusion injury. In this study, the effect of Gadolinium, a synthetic Kupffer cell suppressor, on the reperfusion
injury
was examined using a canine partial liver transplant model.
Methods: About 70% of the liver was harvested and reimplanted in a mongrel recipient dog weighing 20∼25 ㎏. Gadolinium Chloride (10 ㎎/㎏) was infused via the cephalic vein 24 hour before harvesting the partial liver (Gadolinium group,
n=5).
Serum Aspartate Aminotransferase (AST) Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH), and morphological grading of the graft were compared with the control group (n=5). Statistical analysis was done with an independent T-test.
Results: The total ischemic time was 4 hours and 27 minutes on average. One hour after reperfusion, there were no significant differences in the AST, ALP and LDH level, and the pathologic scores. At 48 hours after reperfusion, the AST
(P=0.03)
and LDH (P=0.05) levels were significantly lower in Gadolinium group.
Conclusion: Kupffer cell blockage using the Gadolinium chloride might be an effective way of reducing ischemia reperfusion injury. However, this effect was not evident in the early stages of reperfusion.
키워드
허혈 재관류 손상; 개 간이식; 가돌리늄 클로라이드; Ischemia-Reperfusion injury; Canine liver transplantation; Gadolinium chloride;
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