율무 디클로로메탄 분획물의 항암효과 및 작용기전
In vitro Anticancer Effects and the Mode of Action of Dichloromethane Fraction of Coix lachryma-jobi(adlay)
김성준, 최영현, 이원호, 권은영, 박건영,
소속 상세정보
김성준 ( Kim Seong-Joon )
부산광역시보건환경연구원
최영현 ( Choi Young-Hyun )
미국국립암연구소
이원호 ( Lee Won-Ho )
부산대학교 생물학과
권은영 ( Kwon Eun-Young )
부산대학교 식품영양학과
박건영 ( Park Kun-Young )
부산대학교 식품영양학과
KMID : 0603519980030020122
Abstract
Anticancer effects and the mode of action of dichloromethane fraction from the methanol extract of defatted Coix lachryma-jobi(adlay) were studied. Adlay was defatted with hexane and extracted with methanol. The methanol soluble fraction of the defatted allay was further fractionated with dichloromethane, ethylacetate, butanol and water. Dichloromethane fraction that exhibited the highest antimutagenic and anticancer activities was chosen to investigate the further anticancer effects and the mode of action. Dichloromethane fraction inhibited the growth of MCF-7 and MDA-MB-231 human breast carcinoma cells and the morphological changes of the cancer cells were observed. Also, dichloromethane fraction arrested G2/M phase in the MCF-7 human breast carcinoma cell cycle and induced apoptosis of HL-60 human leukemia cells.
키워드
Coix lachryma-jobi(adlay); Anticancer; Cell cycle; Apoptosis
원문 및 링크아웃 정보
등재저널 정보