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Abstract

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Purpose : This study was designed to demonstrate the potential therapeutic advantage
of 3-dimensional (3-D) treatment planning over the conventional 2-dimensional (2-D)
approach in patients with carcinoma of the nasopharynx.
Materials and Methods : The two techniques were compared both qualitatively and
quantitatively for the boost portion of the treatment (19.8 Gy of a total 70.2 Gy
treatment schedule) in patient with T4. The comparisons between 2-D and 3-D plans
were made using dose statistics, dose-volume histogram, tumor control probabilities. and
normal tissue complication probabilities.
Results : The 3-D treatment planning improved the dose homogeneity in the planning
target volume. In addition. it caused the mean dose of the planning target volume to
increase by 15.2% over 2-D planning. The mean dose to normal structures such as the
temporal lobe, brain stem, carotid gland, and temporomandibular joint was reduced with
the 3-0 plan. The probability of tumor control was increased by 6% with 3-D treatment
planning compared to the 2-D planning, while the probability of normal tissue
complication was reduced.
Conclusion : This study demonstrated the potential advantage of increasing the tumor
control by using 3-D planning, but prospective studies are required to define the true
clinical benefit.

Å°¿öµå

Three-dimensional conformal radiation therapy; Nasopharyngeal carcinoma;

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